Review Therapy of ankylosing spondylitis and other spondyloarthritides: ... [25], sulfasalazine had some effect also on the spinal symptoms of AS patients who had a relatively short disease duration, of less than 6 years. 1. From the Australasian Cochrane Centre. Is sulfasalazine effective in ankylosing spondylitis? At present there is no widely accepted therapy for ankylosing spondylitis (AS), a progressive debilitating disease. Cosentyx (secukinumab), which was approved for AS and PsA in January of 2016, and Taltz (ixekizumab) approved for PsA in December of 2017, and for AS in August of 2019. Reviews on Sulfasalazine. Our findings are summarised below. See all (88) June 17, 2011 — A new study has confirmed etanercept efficacy in early, active ankylosing spondylitis (AS) but did not quite knock sulfasalazine out of contention. We conducted a review of the effect of sulfasalazine for people with ankylosing spondylitis. ANKYLOSING SPONDYLITIS SULFASALAZINE METAANALYSIS This is a Cochrane systematic review (Cochrane Library Issue 2, 2005). The review showed that in people with ankylosing spondylitis: - compared with fake pills, sulfasalazine probably has little or no difference in pain, disease activity, physical function, spinal mobility, patient and physician global assessment; 43% of those users who reviewed Sulfasalazine reported a positive effect, while 42% reported a negative effect. Also known as: Azulfidine, Azulfidine EN-tabs Sulfasalazine has an average rating of 5.5 out of 10 from a total of 111 ratings on Drugs.com. Ankylosing spondylitis (AS), a progressive autoimmune disease, may manifest inflammatory back pain, abnormal posture, and movement disorders, leading to dysfunction, poor quality of life and huge burden on patients, families and society [1,2].In addition, AS is associated with a 14% increase in the risk for malignancy [] as well as a high prevalence of depression [4,5]. Supported by a grant from the World Health Organization. Introduction. Spondylitis Association of America (SAA) is a national, non-profit organization, dedicated to being a leader in the quest to cure ankylosing spondylitis and related diseases, and to empower those affected to live life to the fullest. Ankylosing spondylitis (AS) is a type of arthritis usually in the joints and ligaments of the spine. The effectiveness of sulfasalazine in AS still lacks strong evidence, as well, the magnitude of its benefit is unknown. Sulfasalazine for ankylosing spondylitis. There is evidence that it helps only in 60-70% of cases. A meta-analysis was carried out to assess the effectiveness of s … Chen J, Liu C. J Rheumatol, 33(4):722-731, 01 Apr 2006 Cited by: 35 articles | PMID: 16583475. Review It may also affect shoulders, hips, or other joints and cause tendonitis. This Cochrane review provides the best evidence we have today. 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