76 articles (59 case reports and 17 case series) met the inclusion criteria. In total, 450 cases of hepatitis associated with HSW were reported. | Han X., Wu C. A., Wang W., Liu S., Wang L. Y. Chinese Archives of Traditional Chinese Medicine. 2009;9(20):3968–3982. 2020 Aug 6;12(8):2353. doi: 10.3390/nu12082353. Progress in Modern Biomedicine. One additional reference was identified while searching reference lists of the included papers. Legend says that fo-ti was discovered by a Chinese man, Mr. 2019. 2007;32(4):323–326. Liver damage associated with HSW is reversible, and, after active treatment, the majority can be cured. From Dr. John Chen: Hi brownestrabbit, Yes, I am aware of this and other articles on He Shou Wu. Zhongguo Zhongyao Zazhi. Hu, and L.-C. Fu, “Blood lipid-regulation of stilbene glycoside from, H. H. Cui, Y. Tian, and S. Y. In the Chinese Pharmacopoeia (2010), there are two forms of HSW decoction pieces: raw state (natural root) (Figure 1) and processed form, that is, radix polygoni multiflori preparata (boiled in black-bean liquid according to a traditional process) (Figure 2). The search identified 923 database records, which led to the retrieval of documentation on 103 studies for a full-text review. An extensive search of 6 medical databases was performed up to June 2014. 2015, Article ID 459749, 9 pages, 2015. https://doi.org/10.1155/2015/459749, 1Tianjin University of Traditional Chinese Medicine, 88 Yuquan Road, Tianjin 300193, China, 2Center for Drug Reevaluation, State Food and Drug Administration, Xicheng, Beijing 100045, China, 3Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, 816 Zhenli Road, Tianjin 300150, China, 4Dongzhimen Hospital, Beijing University of Chinese Medicine, Dongcheng, Beijing 100007, China, 5Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China. Fo-ti is also used in TCM for other conditions, including:1 1. Polygonum Multiflorum for Liver Health Animal research shows that P. multiflorum reduces fat deposits inside the liver. He Shou Wu benefits the health of your kidney and liver and supports the … This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Retrospective analysis on cases of liver injury of Polygonum multiflorum. Mao et al., “Comparison of laxative and antioxidant activities of raw, processed and fermented, L. Zhang, X. Yang, and Y. Deng, “Evaluation and consideration on safety information abroad of, L. Lao, G. R. Hamilton, J. Fu, and B. M. Berman, “Is acupuncture safe? : A Systematic Review of Case Reports and Case Series Xiang Lei, 1 Jing Chen, 1 Jingtian Ren, 2 Yan Li, 1 Jingbo Zhai, 1 Wei Mu, 3 Li Zhang, 3 Tinnitus The unprocessed root, kno… National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Brief Answer: Information Detailed Answer: Hello XXXXXXX Fo-Ti is a stimulant laxative, which would explain the diarrhea and abdominal cramps if that is the nature of your stomach pain. To summarize the characteristics and analysis of relevant factors and to give references for prevention and further study of liver damage associated with Polygonum multiflorum Thunb. Liver damage associated with Polygonum multiflorum Thunb. Epub 2017 Mar 29. He shou wu is said to act as an adaptogen, building the body’s defenses against stress, and also to support the balance between yin and yang energies. (HSW), we provide a systematic review of case reports and case series about liver damage associated with HSW. HSW causes liver toxicity and may cause liver damage in different degrees and even lead to death; most of them are much related to long-term and overdose of drugs. The kidneys are often referred to as “the root of vitality” in TCM, since they are involved in essential life processes, including supporting our metabolism, reproduction, blood clean… P. multiflorum and its extracts should be considered hepatotoxic; however, the plant is widely used in traditional Chinese medicine and Ayurvedic medicine for its rejuvenating and toning properties, to increase liver and kidney function, for treatment of cognitive di… Results. Information on author, year of publication, number of patients, disease originally treated, gender, dose and dosage forms, course of taking HSW, clinical manifestations, length of hospitalization, outcome and family history, and recurrence of hepatitis related to HSW were extracted according to the designed data extraction table independently by two authors. However, most HSW induced liver injuries are reversible; after withdrawal of HSW products and corresponding treatments, the vast majority of patients can recover liver function. Lei X, Chen J, Ren J, et al. The case series that reported the average length of hospitalization was about four weeks [18, 21, 23, 28–31]. Xiang Lei and Jing Chen contributed equally to this work. Epub 2017 Jan 24. : A Systematic Review of Case Reports and Case Series", Evidence-Based Complementary and Alternative Medicine, vol. Epub 2014 Nov 18. B. Hu, and X. F. Wang, “Processed, Y. Gao, L. Jia, and K. J. Yu, “Polygoni multiflori, A. Baňárová, T. Koller, and J. Payer, “Toxic hepatitis induced by, L. S. Gao, “One case of drug-induced hepatitis caused by, X. H. Kui and X. Q. Chen, “One case of drug-induced hepatitis caused by, Y. L. Shao and Q. Li, “Two cases of drug-induced hepatitis caused by, Y. C. Hu, H. Z. Li, and R. L. Chen, “One case of drug-induced hepatitis caused by, L. X. Zhen and C. Z. Zeng, “One case of drug-induced hepatitis caused by, Z. X. Li and Z. Zhang, “Two cases of icteric viral hepatitis caused by unprocessed, S. P. Chen, F. M. Tan, and Y. Y. Yang, “One case of acute hepatitis caused by Polygonum multiflorum,”, S. M. Liu, Y. P. Tang, and Y. X. Gong, “One case of acute hepatitis caused by Yishen wufa,”, S. M. Sun, “Two cases of liver damage caused by, M. X. Cao, M. Liu, R. R. Wu, F. Q. Liu, and X. Zhou, “One case of liver damage caused by processed, Y. Liu, W. Y. Chen, Y. Q. Zhao, and H. Xiang, “One case of drug-induced hepatitis caused by Shengfa Yangxue Capsule,”, Y. Q. Yan, “One case of liver damage caused by long-term low-dose administration of, Z. Q. Wu and H. Y. Niu, “One case of severe liver damage caused by, W. Z. Liu, Y. M. Teng, and L. Lei, “One case of acute liver injury caused by Shou-Wu-Wan,”, M. X. Chen, X. Y. Chen, and W. Tang, “Two cases of drug-induced hepatitis caused by, D. W. Yun, X. R. Guo, and X. F. Gao, “One case of liver injury caused by Shou-Wu-Wan,”, M. Furukawa, S. Kasajima, Y. Nakamura et al., “Toxic hepatitis induced by Show-Wu-Pian, a Chinese herbal preparation,”, X. Y. Yan, Q. C. Meng, and Z. S. Yan, “One case of liver damage caused by, R. He, “One case of liver damage caused by, X. Y. Chen, “Plasmapheresis combined with hemofiltration treatment one case drug-induced hepatitis caused by, H. C. Cho, H. J. Min, C. Y. Ha et al., “Reactivation of, F. F. Wang, C. H. Jin, and M. Guan, “Three cases of hepatitis caused by, B. S. Zhu, “One case of drug-induced hepatitis caused by Polygonum multiflorum,”, J. Yang and Z. G. Li, “Two cases of drug-induced hepatitis caused by, A. R. Laird, N. Ramchandani, E. M. Degoma, B. Avula, I. Chen Q. T., Zhuo L. H., Xu W., Huang Z. H., Qiu X. H. Content changes of 5 components in Polygohum muhiflorum during processing. The HSW forms of case reports are shown in Table 4; in terms of usage, all involved Chinese patent medicines are of oral formulation; the types of HSW decoction pieces used included tea, liquor, powder, and decoction. Objective. The length of hospitalization of case reports. : a systematic review of case reports and case series. Moldenke (syn. 2015 Jan 15;159:158-83. doi: 10.1016/j.jep.2014.11.009. To summarize the characteristics and analysis of relevant factors and to give references for prevention and further study of liver damage associated with Polygonum multiflorum Thunb. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. UPLC/MS/MS-Based Metabolomics Study of the Hepatotoxicity and Nephrotoxicity in Rats Induced by. Case reports and case series involving liver damage associated with HSW were included. After screening, articles were read in full and extracted by two independent reviewers (Xiang Lei and Jing Chen). For the 28 cases who consumed Chinese patent medicines in case reports, 17 (17/28, 60.7%) cases are in accordance with the recommended dosage and the remaining are unknown. Polygonum multiflorum, also known as fo-ti or Chinese Knotweed, is a perennial vine native to parts of China. Review articles are excluded from this waiver policy. The effective mechanism of 2, 3, 5, 4′-tetrahy-droxystilbene-2-O-β-D- glucoside in anti-atherosclerosis. J Ethnopharmacol. 2017. Clipboard, Search History, and several other advanced features are temporarily unavailable. Polygonum multiflorum … Q. T. Chen, L. H. Zhuo, W. Xu, Z. H. Huang, and X. H. Qiu, “Content changes of 5 components in, X. Han, C. A. Wu, W. Wang, S. Liu, and L. Y. Wang, “Mechanism research of stilbene glucoside from, X. Gao, Y.-J. There are many signs and symptoms of liver disease. Methods. People should be alert to liver damage when taking HSW preparations. Chinese Pharmacopoeia. Conclusion. (HSW), we provide a systematic review of case reports and case series about liver damage associated with HSW. Reynoutria multiflora (synonyms Fallopia multiflora and Polygonum multiflorum) is a species of flowering plant in the buckwheat family Polygonaceae. Could this illustrate that He Shou Wu (Polygonum Multiflorum) has the potential to damage a healthy liver but could improve a diseased liver? 2012;18(5):66–71. Polygonum multiflorum Thunb. In case series, there is insufficient information on dose and duration of taking HSW of each patient, but some articles indicate that the majority of patients take Chinese patent medicine in accordance with the instructions. Because case series is summary report for multiple patients and because of the lack of description of the individual patient information, the following is mainly an analysis of case reports. Caution: Generally considered safe, there is concern improperly prepared polygonum or over-use over a long period of time may cause liver damage. The classification of the drug of case reports. Polygonum multiflorum (witch hazel) is often recommended for topical use but in traditional Chinese medicine it is also used orally. Methods. Original to traditional Chinese medicine, He Shou Wu, sometimes also called Fo Ti, is a traditional Chinese herb found in south China. Results. multiflorum is also toxic to the kidneys (nephrotoxicity) and the lungs (pulmonary toxicity), particularly after long-term use. A. Khan, and N. Gesundheit, “Acute hepatitis associated with the use of an herbal supplement (, J. L. Yang and Y. J. Dong, “Two cases of liver damage caused by Shou-Wu-Pian,”, P. Fu and Y. Yu, “One case of hepatitis caused by, X. D. Zhao, “One case of acute liver injury caused by Shou-Wu-Wan,”, Z. Li, “Two cases of liver damage caused by, A. Cárdenas, J. C. Restrepo, F. Sierra, and G. Correa, “Acute hepatitis due to Shen-Min: a herbal product derived from, D. Q. Yang, “Polygonum cause severe liver damage,”, B. Panis, D. R. Wong, P. M. Hooymans, P. A. G. M. De Smet, and P. P. R. Rosias, “Recurrent toxic hepatitis in a Caucasian girl related to the use of Shou-Wu-Pian, a Chinese herbal preparation,”, C. Chen, C. J. Zhao, and X. Liver damage associated with Polygonum multiflorum thunb. Cui H. H., Tian Y., Long S. Y. (2015) 2015:459749. Evidence exists of hepatic injury in humans. However, although PM extracts are generally considered to be relatively safe, PM extracts may still show hepatotoxicity. HSW types included raw and processed HSW decoction pieces and many Chinese patent medicines that contain HSW. Chinese Journal of Experimental Traditional Medical Formulae. This review covers a total of 450 cases in 76 articles. While there are many HSW-containing products, the most well-known product is like Shou-Wu-Pian, which is usually consumed as an antiaging product, or as a tonic for dizziness with tinnitus, and also appears to be efficacious in the treatment of premature greying of hair, lumbago, spermatorrhea, leucorrhea, and constipation. The two forms have different properties: the raw HSW is used for detoxification, eliminating carbuncle, preventing malaria, and relaxing bowel, whereas the processed HSW is used for nourishing liver and kidney, supplementing essence and blood, blackening hair, strengthening bones and muscles, eliminating dampness, and reducing lipid [2]. To determine the main clinical and pathological characteristics of liver … In case series, there is insufficient information on HSW forms and usage of each patient, but it is worth noting that, in two case series, the ratio of processed HSW to raw HSW is 5 : 13 and 25 : 11, respectively [18, 22]. The reasons for medication of 72 cases of case reports are shown in Table 3. The herb, scientifically known as Polygonum multiflorum, is known to be … Based on the above information we know that HSW associated with liver injury can occur at any age group and with no gender orientation. Please enable it to take advantage of the complete set of features! This review covers a to… Liver Damage Associated with Polygonum multiflorum Thunb. If fatigue, anorexia, nausea, yellowing of skin and sclera, yellow urine, and other symptoms appear after medication, patients should be alerted to the occurrence of liver damage and promptly stop the medicine and treatment. Immune function 6. He who regained his health, black mane, and vitality through this magical herb. A Candidate Drug for Nonalcoholic Fatty Liver Disease: A Review of Pharmacological Activities of Polygoni Multiflori Radix. High cholesterol 4. This review covers a total of 450 cases in 76 articles. HSW can cause different degrees of liver injury, even need of liver transplantation (2/450), and death (6/450). These include jaundice … -. An extensive search of 6 medical databases was performed up to June 2014. Epub 2018 Dec 6. In case series, the causes of consuming HSW products include grey hair, hair loss, hypertension, coronary heart disease, hyperlipidemia, osteoarthritis, insomnia, dizziness, and health care; the top diseases were gray hair and hair loss [17–21]. ACS Omega. Sign up here as a reviewer to help fast-track new submissions. As a Chinese herb, it was recorded most early in “Kaibao Bencao” published by the imperial court of the Song Dynasty (973-974 A.D.) [1]. In case reports, the length of 64 patients’ hospitalization ranged from 6 to 120 d, with a median of 29.5 (Table 6). Jung S, Son H, Hwang CE, Cho KM, Park SW, Kim H, Kim HJ. HSW is popular in many countries, especially in China. Xiang Lei, Jing Chen, Jingtian Ren, Yan Li, Jingbo Zhai, Wei Mu, Li Zhang, Wenke Zheng, Guihua Tian, Hongcai Shang, "Liver Damage Associated with Polygonum multiflorum Thunb. In addition to two (2/450, 0.4%) cases who received liver transplantation [24, 25] and seven (7/450, 1.6%) who died [18, 23, 25–27], the remaining 441 (441/450, 98%) cases recovered or had liver function improvement after discontinuing HSW products and conservative care. Objective. Overview of Pharmacokinetics and Liver Toxicities of Radix Polygoni Multiflori. NLM Of the 450 patients, two cases who received liver transplantation and seven who died, the remaining 441 cases recovered or had liver function improvement after discontinuing HSW products and conservative care. Case reports and case series are included in the review if they reported factual data on liver damage related to HSW. | Objective. Background & aims: Polygonum Multiflorum Thumb (PMT), an ancient anti-aging Chinese herb known traditionally as He Shou Wu, has side effects of liver toxicity. Case reports and case series involving liver damage associated with HSW were included. 2020 Apr 28;5(18):10489-10500. doi: 10.1021/acsomega.0c00647. Modern pharmacological studies have shown that HSW have the effect of reducing blood lipid and antiarteriosclerosis [3–5], protecting liver [6, 7], enhancing immunologic [8, 9], improving memory, protecting nerve cells, and increasing intelligence [10, 11], antioxidation, antiaging [12, 13], and so forth. Huang Y, Zhao X, Zhang ZT, Chen SS, Li SS, Shi Z, Jing J, Huang A, Guo YM, Bai ZF, Zou ZS, Xiao XH, Wang JB, Niu M. Front Med (Lausanne). Polygonum multiflorum (PM) is a well‐known Chinese herbal medicine that has been reported to induce inflammation‐associated idiosyncratic liver injury. Song, “Correlation analysis of drug-induced liver injury caused by, Y. Wang, “Clinical research of drug-induced liver injury caused by, X. Zhang, X. C. Ding, Y. Yang, P. Zhang, and F. F. Wu, “Clinical analysis of 6 patients with liver diease induced, M. Leng, “One case of acute severe liver injury caused by conventional dose Polygonum multiflorum,”, J. Q. Sheng, “Familial acute liver injury caused by, Q. H. Ye, “One case of acute toxic liver disease caused by, W. Huang, Y. N. Zhang, and R. Sun, “Experimental study on the “Dose-Time-Toxicity” relationship of acute hepatotoxicity induced by different components from, J. Yu, J. Xie, R.-H. Zhao, S.-Q. In 72 cases of case reports, patients ranged in age from 5 to 78 years, with a median of 36.5. Patient details recorded from published case reports. Although only 25 cases of case reports have the HSW dosage information, 14 cases exceed maximum dosages (12 g/d). The results show that, when daily dose is less than 12 g, from the beginning of consuming HSW to the occurrence of liver damage, the median time is 60 days, while when daily dose is more than 12 g the median time is 30 days; this suggested that HSW associated with liver damage has a “dose-time-toxicity” relationship; animal experiments also had proved it [35]. eCollection 2020 May 12. Polygonum multiflorum-Induced Liver Injury: Clinical Characteristics, Risk Factors, Material Basis, Action Mechanism and Current Challenges December 2019 Frontiers in Pharmacology 10:1467 Gao X., Hu Y.-J., Fu L.-C. The root of Reynoutria multiflora (Thunb.) Although many studies suggest that processing could reduce the toxicity of HSW [15, 35], all HSW products may lead to liver damage regardless of herbal processing. eCollection 2020. | In case series, seven articles reported 53 (53/138, 38.4%) cases with liver damage related to HSW many times [17, 21, 27, 29–31]. Fo-ti is POSSIBLY UNSAFE to take by mouth due to concerns that it might cause liver damage in both adults and children. 2017;2017:6238464. doi: 10.1155/2017/6238464. 2020 Apr 20;2020:5462063. doi: 10.1155/2020/5462063. In case reports, 23 (23/72, 31.9%) cases were reported with liver damage associated with HSW for many times, and 3 (3/72, 4.2%) cases had family history of HSW induced hepatitis [32–34]. National Pharmacopoeia Committee. Evid Based Complement Alternat Med. Differences can be resolved through discussion. NA: not available; H: hepatocellular; C: cholestatic; M: mixed; LT: liver transplantation. Sun, “One case of severe liver damage caused by Chinese drugs for invigoration,”, J. Y. Yang, “One case of liver damage caused by, G. J.-H. Park, S. P. Mann, and M. C. Ngu, “Acute hepatitis induced by Shou-Wu-Pian, a herbal product derived from Polygonum multiflorum,”, Z. H. Li, D. M. Gai, and X. R. Zhuang, “Hepatitis attributed to, D. M. Fan and Z. L. Zhou, “One case of liver damage caused by, F. X. Li, “One case of liver injury caused by Shou-Wu-Wan,”, W. F. Zhang, “One case of liver injury caused by Huo-Li-Su,”, J. H. Niu, “One case of severe liver damage caused by Shou-Wu-Pian,”, M. H. He and X. J. Zhen, “Two cases of acute liver damage caused by, P. P.-H. The main reason for using HSW is that patients suffer from gray hair and hair loss; this may be associated with those patients who are more likely to use HSW products, but whether patients suffering from gray hair or hair loss are prone to occurrence of liver damage associated with HSW remains to be further studied. The type of fo-ti typically used is red fo-ti, which is the root boiled in a liquid made with black beans. We are committed to sharing findings related to COVID-19 as quickly as possible. eCollection 2019. The search terms included Polygonum multiflorum, radix polygoni multiflori, He Shou Wu, liver injury, liver damage, liver diseases, hepatitis, and liver failure in English or Chinese. Li YX, Gong XH, Liu MC, Peng C, Li P, Wang YT. eCollection 2020. Fo-ti has been linked to liver damage in several reports, including … This study aimed to identify the genetic basis of susceptibility to PM‐drug‐induced liver … Beijing, China: China Medical Science Press; 2010. The authors declare that they have no financial conflict of interests. To fully understand the characteristics and possible factors of hepatitis associated with HSW, we conduct a comprehensive review of the relevant published literatures; we hope that our findings can provide guidance for clinical medication and scientific research and thus can help to avoid hepatitis induced by HSW in the future. (HSW), we provide a systematic review of case reports and case series about liver damage … 2008;26(8):1687–1689. Insomnia 5. HHS This site needs JavaScript to work properly. Liver damage associated with HSW is reversible, and, after active treatment, the majority can be cured. : a systematic review of case reports and case series. Because more than 30% of patients in case reports and cases series were reported liver damage occurred many times which was induced by HSW, and a few cases have a family history of liver damage induced by HSW; these suggested that HSW associated with liver damage may be related to personal body factors of patients. Blood lipid-regulation of stilbene glycoside from Polygonum multiflorum . In 450 cases, 224 (49.78%) were male and 226 (50.22%) were female. The traditional treasure box of herbs holds a lot of secret ingredients and one of them has to be Polygonum multiflorum, also known as ‘Fo-ti’ or Chinese knotwood. Because HSW induced liver injury is not a specific diagnostic method and some cases included in this review also take other drugs or herbal medicines, so considering the doctors experience, medical technology, and other limiting factors may not show all liver injury is caused by HSW. Toxins (Basel). (HSW), we provide a systematic review of case reports and case series about liver damage associated with HSW. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Aim: The diagnosis of drug-induced liver injury (DILI) remains a challenge and the cases of Polygonum multiflorum Thunb. Traditional usages, botany, phytochemistry, pharmacology and toxicology of Polygonum multiflorum Thunb. Metabolomics Profiling and Diagnosis Biomarkers Searching for Drug-Induced Liver Injury Implicated to. The references of relevant reviews and the included literatures were checked for possible identification of additional studies. The duration of taking HSW of case reports. In traditional Chinese medicine, fo-ti is used as a longevity tonic for greying hair, premature aging, weakness, vaginal discharge, and erectile dysfunction. Reports of hepatitis associated with Polygonum multiflorum have also been reported in the published literature (1–4). Atherosclerosis 2. 2017 May 5;203:182-190. doi: 10.1016/j.jep.2017.03.046. Long, “The effective mechanism of 2, 3, 5, 4′-tetrahy-droxystilbene-2-O-, Y. Y. Yang, H. S. Wang, and S. B. Yang, “The clinical effect of treated nonalcoholic fatty liver disease,”, X. Y. Wei, J. K. Zhang, Y. H. Luo, S. B. Chen, and J. L. Sun, “Antagonistic effect of, C. L. Ge and Y. Liu, “Polysaccharide from, H. N. Kim, Y. R. Kim, J. Y. Jang et al., “Neuroprotective effects of, L. Liu, L. Li, L. Zhao, L. Zhang, Y.-L. Li, and C.-F. Ye, “Effects of 2,3,5,4′-tetrahydroxystilbene-2-O-, J. Yu, J. Xie, X.-J. 2020 Nov 21;12(11):729. doi: 10.3390/toxins12110729. HSW causes liver toxicity and may cause liver damage in different degrees and even lead to death; most of them are much related to long-term and overdose of drugs. So the diarrhea may not be a sign of liver damage… The characteristics of the case reports and case series are shown in Tables 1 and 2. Clinical trials, reviews, commentaries, and other nonrelated literatures were excluded. Of the 450 patients, two cases who received liver transplantation and seven who died, the remaining 441 cases recovered or had liver function improvement after discontinuing HSW products and conservative care. NIH These terms were searched as free-text in the title or the abstract. 10.1155/2015/459749 … Lin L, Ni B, Lin H, Zhang M, Li X, Yin X, Qu C, Ni J. J Ethnopharmacol. : Polygonum multiflorum Thunb., HSW) is a distinguished herb that has been popularly used in traditional Chinese medicine (TCM). Some studies suggested that the adverse reactions of traditional Chinese medicine are closely related to patient self-medication, arbitrarily increase in the dose, or long-term use [39–41]; this systematic review and some papers included in it also have the same standpoint. An extensive search of 6 medical databases was performed up to June 2014. I believe these issues mainly come from two reasons: 1) inappropriate harvest of the herb where the … Z. Yu, “One case of liver damage caused by, M. Y. Huo and S. H. Ling, “Hepatitis due to the concomitant administration of Shou-Wu-Pian and Yangxue Shengfa capsules,”, G. Mazzanti, L. Battinelli, C. Daniele et al., “New case of acute hepatitis following the consumption of Shou Wu Pian, a Chinese herbal product derived from, Z. Y. Shao, “Two cases of liver damage caused by, S. Q. Dai and Y. M. Li, “One case of liver damage caused by, W. D. Yuan, “One case of acute liver injury caused by, J. HSW types included raw and processed HSW decoction pieces and many Chinese patent medicines that contain HSW. With prolonged administration, the toxicity of PM gradually affected the metabolism of vitamin B6, bile acid, and bilirubin, resulting in the increased liver damage… Liu MC, Peng C, li P, Wang W., Liu MC, Peng C, li,... Search History, and, after active treatment, the majority can be cured with abdominal distension abdominal. The use of herbs in complex formulas, but HSW is also often taken as a single herb, H... Age from 5 to 78 years, with a median of 36.5 cases, (...: mixed ; LT: liver transplantation ( 2/450 ), we provide a review. And L.-C. Fu, “ Blood lipid-regulation of stilbene glycoside from, H. H. Cui, Tian! Treatment, the majority can be cured was about four weeks [ 18,,. 10.1155/2015/459749 … from Dr. John Chen: Hi brownestrabbit, Yes, I am aware of this other... 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Well as case reports and case series related to HSW ), we provide a systematic review case. Of its potential side effect on liver injury can occur at any group... To parts of China, black mane, and vitality through this herb! L.-C. Fu, “ Blood lipid-regulation of stilbene glucoside from Polygonum multiflovum Thunb hyperlipemia. Botany, phytochemistry, pharmacology and toxicology of Polygonum multiflorum Wang L. Y, is... Na: not available ; H: hepatocellular ; C: cholestatic ;:! And vitality through this magical herb, China: China medical Science Press ; 2010 will! Activities of Polygoni Multiflori damage associated with Polygonum multiflorum Thunb. is perennial... The effective mechanism of 2, 3, 5, 4′-tetrahy-droxystilbene-2-O-β-D- glucoside in anti-atherosclerosis 5 to 78 years with... Also known as tuber fleeceflower and Chinese … which could cause liver damage associated with HSW were included aware this. 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Hepatotoxicity induced by [ 18, 21, 23, 28–31 ] ( 2/450 ), we a., we provide a systematic review of case reports and case series about liver damage associated HSW., Evidence-Based Complementary and Alternative medicine, vol Nov 21 ; 12 ( ). Reported factual data on liver damage when taking HSW preparations identified 923 database records, which led to the of... And 2 be cured advanced features are temporarily unavailable damage related to COVID-19 medicine, vol study using... Suffered from a known liver condition H: hepatocellular ; C: cholestatic ; M: ;... Publication charges for accepted research articles as well as case reports and case series related to HSW identified 923 records! On hyperlipemia average length of hospitalization was about four weeks [ 18, 21, 23 28–31. Quality Evaluation and identification of additional studies reasons for medication of 72 cases of liver injury, even of. History, and, after active treatment, the majority can be cured reported factual on! Please enable it to take advantage of the chronic hepatotoxicity induced by, C... Pruritus, and death ( 6/450 ) are temporarily unavailable Factors on the above information we know that HSW with... Also used in TCM for other conditions, including:1 1 Toxicities of Radix Polygoni Multiflori in... Extensive search of 6 medical databases was performed up to June 2014, 450 cases in 76 articles 59... The characteristics of the included papers can cause different degrees of liver of! 5, 4′-tetrahy-droxystilbene-2-O-β-D- glucoside in anti-atherosclerosis relatively safe, PM extracts may still show hepatotoxicity ranged in age from to. Although PM extracts are generally considered to be relatively safe, PM extracts are considered. ( 50.22 % ) were female Training Program ( TD12-5032 ), Cho,... 5 to 78 years, with a median of 36.5 W., Liu S., Wang YT cholestatic ;:! Potentially relevant articles were read in full and extracted by two independent reviewers ( Lei! Clipboard, search History, and, after active treatment, the can... As Polygonum multiflorum Thunb., HSW ), we provide a systematic review of case reports the. Safe, PM extracts are generally considered to be relatively safe, PM extracts may still show hepatotoxicity: ;! Na: not available ; H: hepatocellular ; C: cholestatic ; M: mixed ; LT: transplantation. X., Wu C. A., Wang L. Y were retrieved for detailed assessment Tian and! Extracts are generally considered to be relatively safe, PM extracts may still show hepatotoxicity extracted. Drug-Induced liver injury of Polygonum multiflorum Thunb., HSW ), and, after active treatment the... Publication charges for accepted research articles as well as case reports and case series,! Majority can be cured hospitalization was about four weeks [ 18, 21 23!, kno… the root of Reynoutria multiflora ( Thunb. the inclusion.! ) met the inclusion criteria have no financial conflict of interests Pharmacokinetics and liver Toxicities of Radix Polygoni Radix! The HSW dosage information, 14 cases exceed maximum dosages ( 12 g/d ) additional! 12 ( 8 ):2353. doi: 10.3390/toxins12110729 are generally considered to be … liver associated... 23, 28–31 ] polygonum multiflorum liver damage China ( 11 ):729. doi: 10.3390/toxins12110729 study of complete... Of 450 cases in 76 articles ( 59 case reports and 17 case about... Sign up here as a single herb, even need of liver can! Phytochemistry, pharmacology and toxicology of Polygonum multiflorum, is a perennial vine to. Known as Polygonum multiflorum, is a perennial vine native to parts China! Set of features unlimited waivers of publication charges for accepted research articles as well as case reports are shown Tables... Still show hepatotoxicity Diagnosis Biomarkers searching for Drug-Induced liver injury Implicated to effective mechanism of 2 3. Accepted research articles as well as case reports and 17 case series related to HSW for possible of. Polygoni Multiflori Radix in rats: a pilot study by using untargeted metabolomics method ( 6/450 ) Science. Hwang CE, Cho KM, Park SW, Kim HJ H, Hwang CE, Cho KM Park... Tcm ) of China searching for Drug-Induced liver injury Implicated to assessment of chronic!
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