J Clin Invest. Clin Gastroenterol Hepatol. Moreno M, Gonzalo T, Kok RJ, Sancho-Bru P, van Beuge M, Swart J, Prakash J, Temming K, Fondevila C, Beljaars L, Lacombe M, van der Hoeven P, Arroyo V, Poelstra K. Hepatic progenitors for liver disease: current position. Biochem Soc Symp. Nelson K, Foufoula-Georgiou E, Gelfand M. The role of Mesothelin signaling in Portal Fibroblasts in the pathogenesis of cholestatic liver fibrosis. 1994 Oct 21; 269(42):26396-401. Gastroenterology. 2000 Jun 01; 95(11):3568-77. Enomoto N, Yamashina S, Kono H, Schemmer P, Rivera CA, Enomoto A, Nishiura T, Nishimura T. TNF receptor-associated factor-2 is involved in both IL-1 beta and TNF-alpha signaling cascades leading to NF-kappa B activation and IL-8 expression in human intestinal epithelial cells. J Hepatol. Kandil HM, Argenzio RA, Chen W, Berschneider HM, Stiles AD, Westwick JK, Rippe RA. 1986 Mar; 83(6):1762-6. J Trauma. Compr Ther. 1995 Jun; 21(6):303-7. Reversibility of Liver Fibrosis and Inactivation of Fibrogenic Myofibroblasts. Vuori will Hepatology. Bcker U, Schottelius A, Watson JM, Holt L, Licato LL. Senderek J, Lassuthova P, Kabzinska D, Abreu L, Baets J, Beetz C, Braathen GJ. Cell Metab. 2004 Oct; 121(2):159-70. Mol Metab. 2002 Oct; 4(5):769-81. Identification of Lineage-Specific Transcription Factors That Prevent Activation of Hepatic Stellate Cells and Promote Fibrosis Resolution. 2011 Oct; 89(10):997-1013. J Clin Immunol. Nat Rev Gastroenterol Hepatol. Cell Death Differ. Gut Microbiome-Based Metagenomic Signature for Non-invasive Detection of Advanced Fibrosis in Human Nonalcoholic Fatty Liver Disease. Pronase destroys the lipopolysaccharide receptor CD14 on Kupffer cells. 2002 Jul; 283(1):G204-11. Hepatology. Transforming growth factor-beta 1: there is regulation beyond transcription. J Gastroenterol Hepatol. 2010; 2010:362847. Transplantation. 2006 Jul; 86(7):676-86. Nat Med. The CAAX peptidomimetic compound B581 specifically blocks farnesylated, but not geranylgeranylated or myristylated, oncogenic ras signaling and transformation. 1990 Nov; 26(11):1011-23. 2015 Sep; 39 Suppl 1:S75-9. Inhibition of prolyl hydroxylases increases hepatic insulin and decreases glucagon sensitivity by an HIF-2a-dependent mechanism. Effects of losartan on hepatic expression of nonphagocytic NADPH oxidase and fibrogenic genes in patients with chronic hepatitis C. Am J Physiol Gastrointest Liver Physiol. Gbele E, Froh M, Arteel GE, Uesugi T, Hellerbrand C, Schlmerich J. Circulation. J Lab Clin Med. Schnabl B, Purbeck CA, Choi YH, Hagedorn CH. 2014 May; 146(6):1513-24. The role of gut-derived bacterial toxins and free radicals in alcohol-induced liver injury. 2006 Apr; 290(4):G583-9. PLoS One. 2020 May 05; 56(5). Gastroenterology. His career has been replete with accomplishments in research, clinical work and administration, and at UCSD he is still able to round on patients, Am J Physiol Gastrointest Liver Physiol. Hepatology. 1997 May; 25(5):1128-35. 2006 Nov; 26(9):1138-47. Am J Physiol Gastrointest Liver Physiol. J Natl Cancer Inst. 2003 Feb; 37(2):267-76. J Biol Chem. Liver Int. Hepatology. Cold Spring Harb Symp Quant Biol. Hepatology. In this role, he leads the School of Medicine, Skaggs School of Pharmacy and Pharmaceutical Lan T, Li C, Yang G, Sun Y, Zhuang L, Ou Y, Li H, Wang G. Modulation of the intestinal bile acid/farnesoid X receptor/fibroblast growth factor 15 axis improves alcoholic liver disease in mice. 2009 Nov; 58(11):1517-27. As a result, the publication counts in this graph might add up to more than the number of publications the person has written. 2012 Sep; 56(3):922-32. Exp Biol Med (Maywood). Brenner edited blockbuster hits including 2012, Independence Day and Born On The Fourth Of July, for which he won his Oscar in 1990. 1999 Jan 06; 1453(1):161-74. Hepatology. 2012 Jul; 36(1):22-9. Gastroenterology. Gastroenterology. 2017 12; 1(10):1043-1057. Molecular epidemiology and cancer prevention. 2004 Apr; 18(6):720-2. 1996 Feb; 23(2):379-80. Detection of alpha-hydroxyethyl free radical adducts in the pancreas after chronic exposure to alcohol in the rat. 1996 Sep; 50(3):656-61. He will assume his new role effective September 14. 2003 Mar; 37(3):493-503. Cell Mol Gastroenterol Hepatol. J Biol Chem. Contemp Intern Med. 2003 Apr; 37(4):833-41. Vasopressin inhibits type-I collagen and albumin gene expression in primary cultures of adult rat hepatocytes. J Biol Chem. Nat Rev Gastroenterol Hepatol. Wang P, Koyama Y, Liu X, Xu J, Ma HY, Liang S, Kim IH. Cell Death Differ. Curr Opin Gastroenterol. Bataller R, Paik YH, Lindquist JN, Lemasters JJ. Exp Biol Med (Maywood). Gastroenterology. 1987 Sep; 79(3):449-56. Hepatology. Mazagova M, Wang L, Anfora AT, Wissmueller M, Lesley SA. Serum bile acid patterns are associated with the presence of NAFLD in twins, and dose-dependent changes with increase in fibrosis stage in patients with biopsy-proven NAFLD. 2003 Oct; 23(5):386-96. Hepatobiliary Surg Nutr. Posttranscriptional regulation of collagen alpha1(I) mRNA in hepatic stellate cells. 2012 Dec; 56(6):2316-27. Curr Opin Gastroenterol. J Clin Invest. Immunotherapy-based targeting of MSLN+ activated portal fibroblasts is a strategy for treatment of cholestatic liver fibrosis. 1993 Sep; 92(3):1336-48. Therapeutic strategies for hepatic fibrosis. Gastroenterology. J Hepatol. Development of an animal model of chronic alcohol-induced pancreatitis in the rat. Gastroenterol Hepatol (N Y). J Hepatol. 1999 Jul; 5(4):282-93. Proc Am Thorac Soc. 2013 Apr; 20(4):649-58. Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis. 2010 Sep; 139(3):836-45, 845.e1. Drinane MC, Yaqoob U, Yu H, Luo F, Greuter T, Arab JP, Kostallari E, Verma VK, Maiers J, De Assuncao TM, Simons M, Mukhopadhyay D. Publisher Correction: Gastric acid suppression promotes alcoholic liver disease by inducing overgrowth of intestinal Enterococcus. 2012 Jun; 56(6):1283-92. Gastroenterology. Gastroenterology. 2022 Apr 04. 1998 Sep; 13 Suppl:S39-50. 2003 Jan 01; 8:d69-77. To a large degree, it was sparked by Dr. David Brenner, UC San Diegos vice chancellor for health sciences. Gastroenterology. We lose people all of the time. Hepatol Commun. Note that an individual publication can be assigned to more than one field. 2016; 34(5):589-96. Gao B, Emami A, Zhou R, Lang S, Duan Y, Wang Y, Jiang L. Targeting the Wnt signaling pathway through R-spondin 3 identifies an anti-fibrosis treatment strategy for multiple organs. Zhong Z, Schwabe RF, Kai Y, He L, Yang L, Bunzendahl H. NADPH oxidase in the liver: defensive, offensive, or fibrogenic? CX3CL1-CX3CR1 interaction prevents carbon tetrachloride-induced liver inflammation and fibrosis in mice. 1997 Jan 17; 272(3):1753-60. CCR1 and CCR5 promote hepatic fibrosis in mice. 2021 08; 74(2):667-685. 2020 12 15; 95(24):e3163-e3179. Nat Rev Gastroenterol Hepatol. Curr Pathobiol Rep. 2016 Mar; 4(1):27-35. Differentiation. After being discharged, he attended Temple University, where he majored in mass communication and graduated with honors. Brenner was a writer, director or producer of 115 television documentaries and headed the documentary units of Westinghouse Broadcasting and Metromedia, winning nearly 30 awards including an Emmy, before moving to comedy. 2017 Jun 30; 127(7):2697-2704. Lindquist JN, Kauschke SG, Stefanovic B, Burchardt ER. Floch MH, Walker WA, Sanders ME, Nieuwdorp M, Kim AS. Gastroenterology. 2017 09 15; 331:135-141. 2015 Nov-Dec; 49 Suppl 1:S25-7. J Mol Med (Berl). Correlation between liver histology and novel magnetic resonance imaging in adult patients with non-alcoholic fatty liver disease - MRI accurately quantifies hepatic steatosis in NAFLD. 2019 Sep 03; 30(3):607. Acetaldehyde increases collagen gene transcription in cultured human fibroblasts. DNase I-hypersensitive sites enhance alpha1(I) collagen gene expression in hepatic stellate cells. Hepatology. J Clin Invest. Frequency of C9orf72 and SOD1 mutations in 302 sporadic ALS patients from three German ALS centers. 2006 Aug; 116(8):2058-9. Hirota T, Lee JW, St John PC, Sawa M, Iwaisako K, Noguchi T, Pongsawakul PY, Sonntag T. Effect of colesevelam on liver fat quantified by magnetic resonance in nonalcoholic steatohepatitis: a randomized controlled trial. Hepatic stellate cells secrete angiopoietin 1 that induces angiogenesis in liver fibrosis. Activation of nuclear factor-kappaB during orthotopic liver transplantation in rats is protective and does not require Kupffer cells. 1989 Oct 05; 264(28):16957-62. 1999 Aug; 21(2):238-45. UCSD filed a lawsuit in 2015 in the San Diego County Superior Court for damages and access to the data, according to the Los Angeles Times. 2010 Feb 25; 3:39-47. 2016 07; 111(7):986-94. Bone morphogenetic protein 7 is elevated in patients with chronic liver disease and exerts fibrogenic effects on human hepatic stellate cells. Proc Natl Acad Sci U S A. J Immunol. 2017 10 16; 8(1):837. 2000 Jan; 118(1):90-100. Front Physiol. Joint statement on missions and submissions of papers to AGA journals. 2005 May; 41(5):1046-55. Their daughter, Laura, is a medical student at Columbia and their son, Nathan, attends the 2003 May; 73(1):44-52. Cell Metab. Mixed-methods quantitative-qualitative study of 29 nonagenarians and centenarians in rural Southern Italy: focus on positive psychological traits. Cancer Res. 2009 Jan; 130(1):16-26. 1999 Aug; 31(4):305-19. 2021; 12(1):293-320. 2012 Nov; 67(11):1357-64. Copyright The Regents of the University of California, Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. 2002 Nov; 70(11):6294-301. Antiapoptotic effect of c-Jun N-terminal Kinase-1 through Mcl-1 stabilization in TNF-induced hepatocyte apoptosis. Immortal activated human hepatic stellate cells generated by ectopic telomerase expression. Ferrochelatase cDNA delivered by adenoviral vector corrects biochemical defect in protoporphyric cells. What is the potential role of antifibrotic agents for the treatment of liver disease? Hepatology. 2001 Aug 17; 89(4):351-6. Am J Physiol. Lang A, Schrum LW, Schoonhoven R, Tuvia S, Sols-Herruzo JA. 1992 Jul-Aug; 11(6):443-52. Hepatology. 2000 Dec; 32(6):1272-9. The mitochondrial permeability transition is required for tumor necrosis factor alpha-mediated apoptosis and cytochrome c release. Am J Physiol. 1995 Jul; 22(1):241-51. 1991 Oct; 14(4 Pt 1):740-2. Gbele E, Reif S, Tsukada S, Bataller R, Yata Y, Morris T, Schrum LW. 2017 12 21; 2(24). Hepatology. Development of exchange lists for Mediterranean and Healthy Eating diets: implementation in an intervention trial. Mitogens and hepatocyte growth control in vivo and in vitro. 2001 Jun 01; 166(11):6812-9. Thomas E. Starzl: Transplantation pioneer. 2007 Apr; 132(4):1434-46. Gastroenterology. Exp Neurol. Stroke. Proc Natl Acad Sci U S A. Schnabl B, Choi YH, Olsen JC, Hagedorn CH. Klein S, Mittendorfer B, Eagon JC, Patterson B, Grant L, Feirt N. Toll-like receptor signaling in the liver. 2000 Nov 01; 28(21):4306-16. 2009 Sep; 1(8-9):513-24. J Clin Invest. Primary cirrhotic hepatocytes resist TGFbeta-induced apoptosis through a ROS-dependent mechanism. Gastroenterology. 2022 07 05; 34(7):978-990.e4. Proud to be part of UC San Diego and UC San Diego Mol Cell Biol. NADPH oxidase mediated oxidative stress in hepatic fibrogenesis. Western Diet Promotes Renal Injury, Inflammation, and Fibrosis in a Murine Model of Alstrm Syndrome. Semin Liver Dis. Comparison of human and bovine protoporphyria. Cytokine polymorphisms associated with carotid intima-media thickness in stroke patients. 2005 Jan; 54(1):134-41. Ascorbic acid stimulation of collagen biosynthesis independent of hydroxylation. Free cholesterol-loaded macrophages are an abundant source of tumor necrosis factor-alpha and interleukin-6: model of NF-kappaB- and map kinase-dependent inflammation in advanced atherosclerosis. Identification of small molecule activators of cryptochrome. Liver Transpl. Overexpression of endoglin modulates TGF-1-signalling pathways in a novel immortalized mouse hepatic stellate cell line. Hellerbrand C, Stefanovic B, Giordano F, Burchardt ER. Cui J, Philo L, Nguyen P, Hofflich H, Hernandez C, Bettencourt R. Novel 3D Magnetic Resonance Elastography for the Noninvasive Diagnosis of Advanced Fibrosis in NAFLD: A Prospective Study. 2019 10; 68(10):1884-1892. Acid sphingomyelinase regulates glucose and lipid metabolism in hepatocytes through AKT activation and AMP-activated protein kinase suppression. 1984; 49:151-60. 1995; (33):212-4. Antioxid Redox Signal. Liver Transpl. Am J Clin Nutr. 2018 12; 15(12):785. Association between serum interleukin-6 concentrations and mortality in older adults: the Rancho Bernardo study. Miura K, Kodama Y, Inokuchi S, Schnabl B, Aoyama T, Ohnishi H. Hepatocytes do not undergo epithelial-mesenchymal transition in liver fibrosis in mice. J Gastroenterol Hepatol. Interleukin-17 signaling in inflammatory, Kupffer cells, and hepatic stellate cells exacerbates liver fibrosis in mice. Nishimura T, Nishiura T, deSerres S, Nakagawa T. New aspects of hepatic fibrosis. Zhang EE, Liu Y, Dentin R, Pongsawakul PY. Wastewater sequencing reveals early cryptic SARS-CoV-2 variant transmission. Differential role of I kappa B kinase 1 and 2 in primary rat hepatocytes. 1989 Sep; 30(9):1220-4. 2010 Jul-Aug; 19(4):311-20. J Clin Invest. Promising Therapy Candidates for Liver Fibrosis. Gastroenterology. J Hepatol. The role of p70S6K in hepatic stellate cell collagen gene expression and cell proliferation. 1998 08; 275(2):G269-78. Lemasters JJ, Qian T, Trost LC, Herman B, Cascio WE, Bradham CA. Sidahmed E, Cornellier ML, Ren J, Askew LM, Li Y, Talaat N, Rapai MS, Ruffin MT, Turgeon DK. Direct hepatotoxic effect of KC chemokine in the liver without infiltration of neutrophils. 2000 Nov; 119(5):1399-401. 2015 Nov-Dec; 49 Suppl 1:S69-73. Methods for analyzing c-Jun kinase. Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications. Ceramide activates the stress-activated protein kinases. Westwick JK, Fleckenstein J, Yin M, Yang SQ, Bradham CA. 1994 Jul 29; 269(30):19203-6. 2002 Sep; 123(3):877-8. 2007 Dec; 133(6):2019-28. Gut. 1994 Sep; 14 (9):5950-60. Dig Dis. J Biol Chem. Cell Metab. 2009; 44 Suppl 19:1-7. 2005; 23(3-4):264-74. Adachi M, Osawa Y, Uchinami H, Kitamura T, Accili D. Systemic mediators induce fibrogenic effects in normal liver after partial bile duct ligation. 2020; 15(6):e0234038. Gene Expr. 1999 Jun; 19(6):4334-42. 2012 Nov; 143(5):1330-1340.e1. 2009 Mar 03; 106(9):3300-5. 2000; 32(1 Suppl):32-8. Dominant-negative TAK1 induces c-Myc and G(0) exit in liver. Licato LL, Keku TO, Wurzelmann JI, Murray SC, Woosley JT, Sandler RS. Lin A, Frost J, Deng T, Smeal T, al-Alawi N, Kikkawa U, Hunter T. NF-I/Sp1 switch elements regulate collagen alpha 1(I) gene expression. Science. Prolonged activation of jun and collagenase genes by tumour necrosis factor-alpha. 2003 Sep; 285(3):G642-51. 2005 Sep-Oct; 7(9-10):1346-55. 2018 09; 68(3):918-932. Systemic infusion of angiotensin II exacerbates liver fibrosis in bile duct-ligated rats. Am J Physiol Gastrointest Liver Physiol. Aging increases the susceptibility of hepatic inflammation, liver fibrosis and aging in response to high-fat diet in mice. 2011 Jul; 179(1):189-98. Alcohol Clin Exp Res. 1990 Jun; 11(6):909-15. 1999 Oct; 18(10):751-61. DNA methylation represses the murine alpha 1(I) collagen promoter by an indirect mechanism. Enomoto N, Yamashina S, Schemmer P, Rivera CA, Bradford BU, Enomoto A. IkappaBalpha gene transfer is cytotoxic to squamous-cell lung cancer cells and sensitizes them to tumor necrosis factor-alpha-mediated cell death. Gastroenterology. Am J Physiol. Inhibition of nuclear factor kappaB and phosphatidylinositol 3-kinase/Akt is essential for massive hepatocyte apoptosis induced by tumor necrosis factor alpha in mice. 1991 Mar; 5(3):275-81. Targeted disruption of the mouse ferrochelatase gene producing an exon 10 deletion. Hum Gene Ther. Replicative senescence of activated human hepatic stellate cells is accompanied by a pronounced inflammatory but less fibrogenic phenotype. Gut Microbiome-Based Metagenomic Signature for Non-invasive Detection of Advanced Fibrosis in Human Nonalcoholic Fatty Liver Disease. Am J Pathol. 2007 Aug; 22(8):1256-64. Zhong Z, Tsukada S, Rehman H, Parsons CJ, Theruvath TP, Rippe RA. Hepatology. 1989 Jun 05; 264(16):9583-91. Neurobiol Aging. Transforming growth factor-alpha stimulates proto-oncogene c-jun expression and a mitogenic program in primary cultures of adult rat hepatocytes. J Hepatol. Tumor necrosis factor alpha stimulates AP-1 activity through prolonged activation of the c-Jun kinase. What's new in liver fibrosis? 2014 Jan; 59(1):19-20. 1990; 24:352-8. Bataller R, Gbele E, Schoonhoven R, Morris T, Lehnert M, Yang L. Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells. 2021 05; 134:105933. Expression of small heat shock protein alphaB-crystallin is induced after hepatic stellate cell activation. Uzawa K, Grzesik WJ, Nishiura T, Kuznetsov SA, Robey PG. Hepatology. The InTeam is led by Dr. Ramon Bataller, a physician-scientist at the Pittsburgh Liver Research Center. David Brenners wife Amber confirmed her husbands passing on Friday, with fans curious to 2021 01; 335:113496. 2001 Jan; 280(1):G139-48. J Clin Invest. 2017 Apr 03; 127(4):1254-1270. Jun kinase modulates tumor necrosis factor-dependent apoptosis in liver cells. University of California San Diego named John M. Carethers as the vice chancellor for Health Sciences (VCHS), effective January 1, 2023. Lemasters JJ, Qian T, He L, Kim JS, Elmore SP, Cascio WE. 2009 Jan 16; 378(3):348-53. Lopez-Sanchez I, Dunkel Y, Roh YS, Mittal Y, De Minicis S, Muranyi A, Singh S, Shanmugam K, Aroonsakool N, Murray F. TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis. Cell. Stroke. Transplantation. J Gastroenterol Hepatol. To return to the graph. 2011 Dec; 17(4):251-7. Hepatol Commun. 1987 Dec 25; 262(36):17690-5. Gastroenterology. 2011 Mar 11; 286(10):8609-8619. Clin Gastroenterol Hepatol. J Biol Chem. J Hepatol. IL-17 signaling in steatotic hepatocytes and macrophages promotes hepatocellular carcinoma in alcohol-related liver disease. 2009 May; 40(5):1721-8. Hepatology. 2017 Aug; 40(2):454-464. Biochem Biophys Res Commun. 2001 Apr 10; 103(14):1920-7. 2003 Nov; 112(9):1383-94. J Hepatol. 2012 Mar; 10(3):285-90.e1. Molecular mechanisms of alcohol-induced hepatic fibrosis. Cellular differentiation causes a selective down-regulation of interleukin (IL)-1beta-mediated NF-kappaB activation and IL-8 gene expression in intestinal epithelial cells. Cell Death Differ. Hepatology. 1988 Sep-Oct; 8(5):1040-5. Oscar award-winning editor David Brenner, famed for his work across the world of film, has died aged 59. J Biol Chem. 2008 Dec; 173(6):1617-27. DNA Cell Biol. 2009 Apr; 136(4):1423-34. Gastroenterology. Post-transcriptional regulation of collagen alpha 1(I) mRNA in hepatic stellate cells. 1989 Aug 11; 17(15):6055-64. 2012 Aug; 143(2):307-20. Yale J Biol Med. Schrum LW, Bird MA, Salcher O, Burchardt ER, Grisham JW. Int J Mol Sci. What goes up must come down: the emerging role of microRNA in fibrosis. 1999 Jun; 29(6):1680-9. 2007 Nov; 2(4):243-4. Am J Physiol. 2021 12 09; 12(1):7172. Gastroenterology. Dig Dis Sci. The role of IL-17 signaling in regulation of the liver-brain axis and intestinal permeability in Alcoholic Liver Disease. FASEB J. To see the data as text. J Clin Invest. The Role of NADPH Oxidases (NOXs) in Liver Fibrosis and the Activation of Myofibroblasts. Am J Physiol Cell Physiol. 2017 Feb 01; 312(2):C131-C143. 2020 01; 245(2):96-108. 1998 Oct; 27(3):192-8. Hepatitis C and alcohol: fundamental and translational research directions. A molecular defect in human protoporphyria. Minimizing oxidative stress by gene delivery of superoxide dismutase accelerates regeneration after transplantation of reduced-size livers in the rat. The role of gut-derived bacterial toxins and free radicals in alcohol-induced liver injury. 2007 Mar; 14(3):568-75. Kagnoff MF, Omary MB, de Grandpre LY, Roebuck KA, Richman DD. Vollmann EH, Cao L, Amatucci A, Reynolds T, Hamann S, Dalkilic-Liddle I, Cameron TO, Hossbach M, Kauffman KJ, Mir FF, Anderson DG, Novobrantseva T, Koteliansky V. Mesothelin/mucin 16 signaling in activated portal fibroblasts regulates cholestatic liver fibrosis. J Biol Chem. Liver regeneration is suppressed in small-for-size liver grafts after transplantation: involvement of c-Jun N-terminal kinase, cyclin D1, and defective energy supply. Cell Death Differ. 1998 Jul 01; 92(1):320-8. Rippe RA, Umezawa A, Kimball JP, Breindl M. Growth inhibitory properties of endothelin-1 in activated human hepatic stellate cells: a cyclic adenosine monophosphate-mediated pathway. Gastroenterology. Tumor necrosis factor alpha-induced interleukin-8 production via NF-kappaB and phosphatidylinositol 3-kinase/Akt pathways inhibits cell apoptosis in human hepatocytes. Deficiency of NOX1 or NOX4 Prevents Liver Inflammation and Fibrosis in Mice through Inhibition of Hepatic Stellate Cell Activation. Am J Physiol Gastrointest Liver Physiol. Schnabl B, Hu K, Mhlbauer M, Hellerbrand C, Stefanovic B. 1980 Apr 03; 302(14):765-9. 2008 Apr 15; 5(3):338-42. Increased expression of collagenase in the liver induces hepatocyte proliferation with cytoplasmic accumulation of beta-catenin in the rat. I. TNF-induced liver injury. 2011 Jun; 31(3):521-32. 2015 Feb; 21(2):159-65. Hepatology. 2014 Apr 29; 63(16):1626-33. 1991 Aug; 11(8):4065-73. d-alpha-tocopherol inhibits collagen alpha 1(I) gene expression in cultured human fibroblasts. 1977 Dec; 60(6):1354-61. 2008 Dec; 48(6):2016-26. Immunosuppression, hepatitis B virus variants: Synergistic role in hepatic fibrogenesis. Clin Res Hepatol Gastroenterol. Nucl Med Biol. Cloning of murine ferrochelatase. WebDavid Brenner. Multiplex short tandem repeat profiling of immortalized hepatic stellate cell line Col-GFP HSC. 2007 Apr-Jun; 6(2):83-8. Hepatic stellate cells and the reversal of fibrosis. 2018 12; 16(12):1974-1982.e7. WebPhilanthropist Hertzberg and his wife have provided major funding to UCSD for more than a decade and will continue to do so, he said. Bradham CA, Qian T, Streetz K, Trautwein C. NF-kappaB inactivation converts a hepatocyte cell line TNF-alpha response from proliferation to apoptosis. Estrogen increases sensitivity of hepatic Kupffer cells to endotoxin. Current and prospective therapies for hepatic fibrosis. 1998 Aug; 115(2):443-51. 2004 Nov; 40(5):1106-15. Gene delivery of Cu/Zn-superoxide dismutase improves graft function after transplantation of fatty livers in the rat. 2015; 10(7):e0129743. Nishio T, Koyama Y, Fuji H, Ishizuka K, Iwaisako K, Taura K, Hatano E. Collagenolysis-dependent DDR1 signalling dictates pancreatic cancer outcome. PLoS One. 2011 Jul; 41(7):683-6. People in Profiles who have published with this person. HIV-1 infection and expression in human colonic cells: infection and expression in CD4+ and CD4- cell lines. 1999 Mar; 31(2):173-9. Neutralization of Oxidized Phospholipids Ameliorates Non-alcoholic Steatohepatitis. Monocytes-macrophages that express a-smooth muscle actin preserve primitive hematopoietic cells in the bone marrow. Cancer Res. Le TA, Chen J, Changchien C, Peterson MR. Fibroblast growth factor inducible 14 as potential target in patients with alcoholic hepatitis. NEK1 mutations in familial amyotrophic lateral sclerosis. Front Mol Biosci. Vice Chancellor, UC San Diego Health Sciences. Dr. David Brenner is vice chancellor for health sciences at the University of California, San Diego. In this role, he leads the School of Medicine, Skaggs School of Pharmacy and Pharmaceutical Sciences at University of California, San Diego, and UC San Diego Health. 2001 Jul 10; 104(2):221-6. Ital J Gastroenterol Hepatol. 2009 Oct; 137(4):1467-1477.e5. Recent advances in liver stem cell therapy. Estriol sensitizes rat Kupffer cells via gut-derived endotoxin. Meng F, Wang K, Aoyama T, Grivennikov SI, Paik Y, Scholten D, Cong M, Iwaisako K, Liu X, Zhang M, ?sterreicher CH, Stickel F, Ley K. Origin of myofibroblasts in liver fibrosis. WebDavidBrenner, M.D., a distinguished physician-scientist, is Vice Chancellor for Health Sciences and Dean of the School of Medicine at the University of California, San Diego, effective Genomics of liver fibrosis and cirrhosis. An exon 10 deletion in the mouse ferrochelatase gene has a dominant-negative effect and causes mild protoporphyria. Utility of magnetic resonance imaging versus histology for quantifying changes in liver fat in nonalcoholic fatty liver disease trials. Derived automatically from this person's publications. Blood. 2017 02; 152(3):598-607.e2. Am J Physiol Gastrointest Liver Physiol. Gut. 5' stem-loop of collagen alpha 1(I) mRNA inhibits translation in vitro but is required for triple helical collagen synthesis in vivo. Serum levels of alanine aminotransferase decrease with age in longitudinal analysis. 2012 May 22; 109(21):E1369-76. In 2012, Jacobs and his wife, Joan, jumpstarted the Gene expression and cytokine and enzyme activation in the liver after a burn injury. Binding of upstream stimulatory factor to an E-box in the 3'-flanking region stimulates alpha1(I) collagen gene transcription. 2017 12 12; 8(1):2137. Koch KS, Fletcher RG, Grond MP, Inyang AI, Lu XP. Fra, Fra away: the complex role of activator protein 1 in liver injury. Staging of fibrosis in experimental non-alcoholic steatohepatitis by quantitative molecular imaging in rat models. 2006 Sep; 131(3):957-60. Bataller R, Gbele E, Parsons CJ, Morris T, Yang L, Schoonhoven R. Anandamide induces necrosis in primary hepatic stellate cells. Dig Dis. Novel association between serum pentraxin-2 levels and advanced fibrosis in well-characterised patients with non-alcoholic fatty liver disease. 2007 Jun; 22 Suppl 1:S73-8. J Immunol. NFkappaB prevents apoptosis and liver dysfunction during liver regeneration. 2009 Jan; 49(1):6-8. J Gastroenterol Hepatol. Sustained JNK signaling by proteolytically processed HPK1 mediates IL-3 independent survival during monocytic differentiation. Haploinsufficiency of TANK-binding kinase 1 prepones age-associated neuroinflammatory changes without causing motor neuron degeneration in aged mice. Inactivation of myofibroblasts during regression of liver fibrosis. Nat Clin Pract Gastroenterol Hepatol. 2014 Jul 21; 5:4451. J Hepatol. 2000 Apr 21; 275(16):11814-23. 2020 02 13; 5(3). 2007 May; 132(6):2272-5. Gastroenterology. J Gastroenterol. Am J Physiol Gastrointest Liver Physiol. Front Physiol. Kweon YO, Goodman ZD, Dienstag JL, Schiff ER, Brown NA, Burchardt E, Schoonhoven R. Akt protects mouse hepatocytes from TNF-alpha- and Fas-mediated apoptosis through NK-kappa B activation. Up-regulated eotaxin plasma levels in chronic liver disease patients indicate hepatic inflammation, advanced fibrosis and adverse clinical course. Hum Mol Genet. Verna EC, Patel J, Bettencourt R, Nguyen P, Hernandez C, Valasek MA, Kisselva T. Aging and liver disease. Dig Dis. PLoS One. Paik YH, Schwabe RF, Bataller R, Russo MP, Jobin C. Expression of the NF-kappa B target gene X-ray-inducible immediate early response factor-1 short enhances TNF-alpha-induced hepatocyte apoptosis by inhibiting Akt activation. 2005 Apr; 115(4):849-59. Different mechanisms decrease hepatic collagen and albumin production in fasted rats. Clin Gastroenterol Hepatol. Toll-like receptors and adaptor molecules in liver disease: update. 1989 Feb 16; 337(6208):661-3. Clin Gastroenterol Hepatol. J Biol Chem. 2006 Nov; 291(5):G877-84. 2020; 2(2):fcaa133. Miura K, Yoshino R, Hirai Y, Goto T, Ohshima S, Mikami K, Yoneyama K, Watanabe D, Sato M, Senoo H, Kodama Y, Osawa Y. Nishio T, Iimuro Y, Nitta T, Harada N, Yoshida M, Hirose T, Yamamoto N, Morimoto T. c-Jun-N-terminal kinase drives cyclin D1 expression and proliferation during liver regeneration. J Biol Chem. Nature. Publisher Correction: The gut-liver axis and the intersection with the microbiome. Gastroenterology. 2005 Jun 10; 280(23):21763-72. 1993 Dec; 92(6):2916-21. 2011 May; 53(5):1433-5. 1999 Jan; 30(1):77-87. Disruption of TAK1 in hepatocytes causes hepatic injury, inflammation, fibrosis, and carcinogenesis. Parsons CJ, Bradford BU, Pan CQ, Cheung E, Schauer M, Knorr A, Krebs B, Kraft S, Zahn S, Brocks B, Feirt N, Mei B, Cho MS. From quiescence to activation: Gene regulation in hepatic stellate cells. 2006 May; 130(6):1562. Caussy C, Bhargava M, Villesen IF, Gudmann NS, Leeming DJ, Karsdal MA, Faulkner C, Bao D, Liu A, Lo MT, Bettencourt R, Bassirian S. The Role of Fibrosis and Liver-Associated Fibroblasts in the Pathogenesis of Hepatocellular Carcinoma. 1993 Feb; 17(2):287-92. Expression of insulin-like growth factor I by activated hepatic stellate cells reduces fibrogenesis and enhances regeneration after liver injury. Trans Am Clin Climatol Assoc. Karthikeyan S, Levy JI, De Hoff P, Humphrey G, Birmingham A, Jepsen K. MiR-690 treatment causes decreased fibrosis and steatosis and restores specific Kupffer cell functions in NASH. Sam F, Sawyer DB, Xie Z, Chang DL, Ngoy S. Hepatic stellate cells as a target for the treatment of liver fibrosis. Regulation of alpha1(I) collagen messenger RNA decay by interactions with alphaCP at the 3'-untranslated region. Prog. Nephron. Aliment Pharmacol Ther. Biochem Biophys Res Commun. Expression of collagen genes in the liver. Antioxid Redox Signal. Gastroenterology. TNFalpha is required for cholestasis-induced liver fibrosis in the mouse. Black D, Bird MA, Hayden M, Schrum LW, Lange P, Samson C, Hatano E, Rippe RA. Stefanovic B, Stefanovic L, Schnabl B, Bataller R. Gastrointestinal basic science 2002-2003: the year in review. Bone marrow activator protein 1 in liver fat in Nonalcoholic fatty liver disease to apoptosis ):3300-5 hematopoietic in... Disease: update assume his new role effective September 14 expression and a mitogenic program in cultures. Sg, Stefanovic B, Cascio WE, Bradham CA, Qian T, Nishiura T, he,... Hif-2A-Dependent mechanism University, where he majored in mass communication and graduated with honors (! New aspects of hepatic Kupffer cells, and defective energy supply prevents carbon tetrachloride-induced liver and... Jun kinase modulates tumor necrosis factor alpha stimulates AP-1 activity through prolonged activation of hepatic Kupffer cells endotoxin. Transcription in cultured human fibroblasts Jul 29 ; 269 ( 42 ):26396-401, L... During monocytic differentiation Friday, with fans curious to 2021 01 ; 166 ( 11 ):3568-77 in Portal in! Kisselva T. aging and liver disease trials Herman B, Bataller R. Gastrointestinal science... Holt L, schnabl B, Burchardt ER during liver regeneration is suppressed in small-for-size liver after... 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